Title : Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine.

Pub. Date : 2008 Mar 5

PMID : 18321387






2 Functional Relationships(s)
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1 BACKGROUND: The vaccinia virus (VV) F2L gene encodes a functional deoxyuridine triphosphatase (dUTPase) that catalyzes the conversion of dUTP to dUMP and is thought to minimize the incorporation of deoxyuridine residues into the viral genome. 2'-deoxyuridylic acid Deoxyuridine triphosphatase Drosophila melanogaster
2 The absence of dUTPase should reduce cellular dUMP pools and may result in a reduced conversion to dTMP by thymidylate synthetase or an increased reliance on the salvage of thymidine by the viral thymidine kinase. 2'-deoxyuridylic acid Deoxyuridine triphosphatase Drosophila melanogaster