Title : Benzyl ether-linked glucuronide derivative of 10-hydroxycamptothecin designed for selective camptothecin-based anticancer therapy.

Pub. Date : 2008 Mar 27

PMID : 18318465






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1 A beta-glucuronidase-activated prodrug approach was applied to 10-hydroxycamptothecin, a Camptotheca alkaloid with promising antitumor activity but poor water solubility. 10-hydroxycamptothecin glucuronidase beta Homo sapiens