Pub. Date : 2008 Oct
PMID : 18312488
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | GABA control of GnRH release from the ewe hypothalamus in vitro: sensitivity to oestradiol. | gamma-Aminobutyric Acid | gonadotropin releasing hormone 1 | Homo sapiens |
| 2 | The present study examines the involvement of GABA(A or B) receptors in gonadotrophin-releasing hormone (GnRH) release in vitro and determines whether oestradiol modulates gamma-aminobutyric acid (GABA)-GnRH interaction. | gamma-Aminobutyric Acid | gonadotropin releasing hormone 1 | Homo sapiens |
| 3 | The present study examines the involvement of GABA(A or B) receptors in gonadotrophin-releasing hormone (GnRH) release in vitro and determines whether oestradiol modulates gamma-aminobutyric acid (GABA)-GnRH interaction. | gamma-Aminobutyric Acid | gonadotropin releasing hormone 1 | Homo sapiens |
| 4 | However, GnRH increased (p < 0.05) after exposure to 10 mM GABA(A or B) antagonists (bicuculline or CGP52432, respectively). | gamma-Aminobutyric Acid | gonadotropin releasing hormone 1 | Homo sapiens |
| 5 | The GABA(A) antagonist stimulated greater sustained GnRH release (p < 0.05) in the absence of oestradiol than in its presence. | gamma-Aminobutyric Acid | gonadotropin releasing hormone 1 | Homo sapiens |
| 6 | Only after exposure of hypothalamic slices to the GABA(A) antagonist, did the hypothalamic eluate stimulate luteinizing hormone release from pituitary fragments (p < 0.05) confirming that the GABA(A) antagonist stimulated release of biologically active GnRH. | gamma-Aminobutyric Acid | gonadotropin releasing hormone 1 | Homo sapiens |
| 7 | In summary, GnRH release from the hypothalamus is predominantly under GABA(A) receptor inhibitory control and this is attenuated in the presence of oestradiol. | gamma-Aminobutyric Acid | gonadotropin releasing hormone 1 | Homo sapiens |