Title : The contributions of cytochromes P450 3A4 and 3A5 to the metabolism of the phosphodiesterase type 5 inhibitors sildenafil, udenafil, and vardenafil.

Pub. Date : 2008 Jun

PMID : 18308836






2 Functional Relationships(s)
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1 We investigated the contributions of the CYP3A4 and CYP3A5 isoforms to the metabolism of the phosphodiesterase type 5 inhibitors (PDE5Is) sildenafil, udenafil, and vardenafil. Sildenafil Citrate cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Recombinant CYP3A4 and CYP3A5 both produced N-desalkyl metabolites of sildenafil, udenafil, and vardenafil. Sildenafil Citrate cytochrome P450 family 3 subfamily A member 4 Homo sapiens