Pub. Date : 2008 Feb
PMID : 18281521
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study, we have analyzed the effects of calcitriol treatment on the expression and activity of the UDP-glucuronosyltransferase (UGT) 2B15 and 2B17 in prostate cancer LNCaP and 22Rv1 cells. | Calcitriol | UDP glucuronosyltransferase family 2 member B15 | Homo sapiens |
| 2 | By contrast, transient transfection and site-directed mutagenesis experiments revealed that calcitriol down-regulates UGT2B15 promoter activity through a responsive region between positions -171 and -113 bp. | Calcitriol | UDP glucuronosyltransferase family 2 member B15 | Homo sapiens |
| 3 | In conclusion, the present study identifies the vitamin D receptor activator calcitriol as a negative regulator of the UGT2B15- and UGT2B17-dependent inactivation of androgens in prostate cancer LNCaP cells. | Calcitriol | UDP glucuronosyltransferase family 2 member B15 | Homo sapiens |