Title : A combination of sulindac and arsenic trioxide synergistically induces apoptosis in human lung cancer H1299 cells via c-Jun NH2-terminal kinase-dependent Bcl-xL phosphorylation.

Pub. Date : 2008 Sep

PMID : 18281123






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The c-Jun NH(2)-terminal kinase (JNK) was activated downstream of ROS production in H1299 cells. Reactive Oxygen Species mitogen-activated protein kinase 8 Homo sapiens
2 The c-Jun NH(2)-terminal kinase (JNK) was activated downstream of ROS production in H1299 cells. Reactive Oxygen Species mitogen-activated protein kinase 8 Homo sapiens
3 In conclusion, in H1299 human NSCLC cells, sulindac and ATO synergistically induce a high degree of apoptosis, which is mediated by the ROS-dependent JNK activation pathway via Bcl-xL phosphorylation. Reactive Oxygen Species mitogen-activated protein kinase 8 Homo sapiens