Pub. Date : 2008 May 1
PMID : 18275979
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rapid activation of ERK1/2 and AKT in human breast cancer cells by cadmium. | Cadmium | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | Cadmium (Cd), an endocrine disruptor, can induce a variety of signaling events including the activation of ERK1/2 and AKT. | Cadmium | mitogen-activated protein kinase 3 | Homo sapiens |
| 3 | Cadmium (Cd), an endocrine disruptor, can induce a variety of signaling events including the activation of ERK1/2 and AKT. | Cadmium | mitogen-activated protein kinase 3 | Homo sapiens |
| 4 | Specifically, treatment of MCF-7 cells, that express ER alpha, ER beta and GPR30, to 0.5-10 microM Cd for only 2.5 min resulted in transient phosphorylation of ERK1/2. | Cadmium | mitogen-activated protein kinase 3 | Homo sapiens |
| 5 | In SK-BR-3 cells, that express only GPR30, Cd also caused a transient activation of ERK1/2, but not of AKT. | Cadmium | mitogen-activated protein kinase 3 | Homo sapiens |
| 6 | While the estrogen receptor antagonist, ICI 182,780, did not prevent the effect of Cd on these signals, specific siRNA against hER alpha significantly reduced Cd-induced activation of ERK1/2 and completely blocked the activation of AKT. | Cadmium | mitogen-activated protein kinase 3 | Homo sapiens |
| 7 | It is concluded that Cd, like estradiol, can cause rapid activation of ERK1/2 and AKT and that these signaling events are mediated by possible interaction with membrane ER alpha and GPR30, but not ER beta. | Cadmium | mitogen-activated protein kinase 3 | Homo sapiens |