Title : Diphenyl diselenide confers neuroprotection against hydrogen peroxide toxicity in hippocampal slices.

Pub. Date : 2008 Mar 14

PMID : 18272143






2 Functional Relationships(s)
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1 Even though H2O2 (2 mM) did not alter p38 MAPK and JNK1/2 phosphorylation in hippocampal slices, it stimulated ERK1/2 phosphorylation and the co-incubation with (PhSe)2 (10 microM) blocked this effect. Hydrogen Peroxide mitogen activated protein kinase 3 Rattus norvegicus
2 Taken together, the present results indicate that (PhSe)2 exerts protective effects against H2O2-induced oxidative damage in hippocampal slices and avoided the increase in ERK1/2 phosphorylation promoted by H2O2. Hydrogen Peroxide mitogen activated protein kinase 3 Rattus norvegicus