Title : Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway.

Pub. Date : 2008 Apr 15

PMID : 18270325






1 Functional Relationships(s)
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1 Taken together, we show that ceramide exhibits a mechanism of transcriptional regulation involving up-regulation of Txnip expression, also induced by etoposide, which results in ASK1 activation, ER stress, and p38 and JNK phosphorylation, all leading to apoptosis. Etoposide mitogen-activated protein kinase 8 Homo sapiens