Title : Neuroprotective effects of serotonin 5-HT 1A receptor activation against ischemic cell damage in gerbil hippocampus: Involvement of NMDA receptor NR1 subunit and BDNF.

Pub. Date : 2008 Mar 14

PMID : 18269931






1 Functional Relationships(s)
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1 The results indicate that both NR1 subunit phosphorylation and the neurotrophin BDNF account, at least in part, for the neuroprotective effect of 8-OH-DPAT on cell damage induced by global ischemia in the gerbil hippocampus and support the potential interest of 5-HT1A receptor activation in the search for neuroprotective strategies. 8-Hydroxy-2-(di-n-propylamino)tetralin 5-hydroxytryptamine receptor 1A Homo sapiens