Pub. Date : 2008 May
PMID : 18267976
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The isoflavone derivatives showed differential effects on the activation and expression of sirtuin (SIRT)1, a deacetylase and activator of PGC-1alpha. | Isoflavones | sirtuin 1 | Homo sapiens |
| 2 | We have identified a series of substituted isoflavones that produce mitochondrial biogenesis through PGC1alpha and increased SIRT1 activity and/or expression, independently of the estrogen receptor. | Isoflavones | sirtuin 1 | Homo sapiens |
| 3 | Furthermore, different structural components are responsible for the activities of isoflavones: the hydroxyl group at position 7 is required SIRT1 activation, a hydroxyl group at position 5 blocks SIRT1 activation, and the loss of the phenyl ring at position 3 or the 4"-hydroxy or -methoxy substituent blocks increased SIRT1 expression. | Isoflavones | sirtuin 1 | Homo sapiens |
| 4 | Furthermore, different structural components are responsible for the activities of isoflavones: the hydroxyl group at position 7 is required SIRT1 activation, a hydroxyl group at position 5 blocks SIRT1 activation, and the loss of the phenyl ring at position 3 or the 4"-hydroxy or -methoxy substituent blocks increased SIRT1 expression. | Isoflavones | sirtuin 1 | Homo sapiens |
| 5 | Furthermore, different structural components are responsible for the activities of isoflavones: the hydroxyl group at position 7 is required SIRT1 activation, a hydroxyl group at position 5 blocks SIRT1 activation, and the loss of the phenyl ring at position 3 or the 4"-hydroxy or -methoxy substituent blocks increased SIRT1 expression. | Isoflavones | sirtuin 1 | Homo sapiens |