Title : Involvement of ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4.

Pub. Date : 1991 Apr 15

PMID : 1826565






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The ras gene product (p21) is a GTP-binding protein, and the activity of the protein is regulated by bound GDP/GTP. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens
2 The ras gene product (p21) is a GTP-binding protein, and the activity of the protein is regulated by bound GDP/GTP. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens
3 Recent studies have shown that a certain class of growth factors stimulates the formation of active p21-GTP complexes in fibroblasts and that oncogene products with enhanced tyrosine kinase activities have a similar effect on ras p21. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens
4 We have measured the ratio of active GTP-bound p21 to total p21 in several lymphoid and myeloid cell lines in order to understand the role of ras in the proliferation of these cells. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens
5 Interleukin 2 (IL-2), IL-3, and granulocyte/macrophage colony-stimulating factor (GM-CSF) enhance the formation of the active p21.GTP, whereas IL-4 has no effect on p21-bound GDP/GTP. Guanosine Triphosphate H3 histone pseudogene 16 Homo sapiens