Title : [Clinico-diagnostic significance of cytokine activation and changes of morphofunctional parameters of the heart in patients with chronic heart failure and possibilities of correction of revealed disturbances with simvastatin].

Pub. Date : 2007

PMID : 18260853






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1 At the background of therapy with simvastatin we noted significant lowering of proinflammatory cytokines (TNFalpha, IL-1beta, IL-6, IL-8) in blood serum irrespective of level of low density lipoprotein cholesterol, betterment of functional state of the left ventricle, positive clinical dynamics of CHF. Simvastatin interleukin 6 Homo sapiens