Title : Akt inactivates ERK causing decreased response to chemotherapeutic drugs in advanced CaP cells.

Pub. Date : 2008 Mar 1

PMID : 18256541






1 Functional Relationships(s)
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1 Prolonged treatment with two commonly-used chemotoxic compounds, doxorubicin and paclitaxel, caused increased activation of ERK in PTEN-positive DU145 cells, but not PTEN-negative PC3 cells. Doxorubicin mitogen-activated protein kinase 1 Homo sapiens