Title : Contribution of the N-glucuronidation pathway to the overall in vitro metabolic clearance of midazolam in humans.

Pub. Date : 2008 May

PMID : 18256203






1 Functional Relationships(s)
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1 In the context of the in vitro study of CYP3A4-mediated DDI using MDZ and ketoconazole, direct MDZ N-glucuronidation may partly compensate the decrease in MDZ metabolic clearance caused by the addition of the inhibitor, thus potentially leading to underestimation, at least in vitro, of the extent of DDI. Nitrogen cytochrome P450 family 3 subfamily A member 4 Homo sapiens