Title : BACE1 inhibitors: optimization by replacing the P1' residue with non-acidic moiety.

Pub. Date : 2008 Mar 1

PMID : 18249539






1 Functional Relationships(s)
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1 Herein, we replaced acidic moieties at the P(4) position with other hydrogen bond acceptor groups, and these inhibitors exhibited improved BACE1 inhibitory activities in cultured cells. Hydrogen beta-secretase 1 Homo sapiens