Pub. Date : 1976 Jun 15
PMID : 182488
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Binding of a metyrapone spin label to microsomal cytochrome P-450. | Metyrapone | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 2 | Probing of the active site of microsomal cytochrome P-450 was carried out with a spin label derived from 2-methyl-1,2-bis(3-pyridyl)-1-propanone (metyrapone). | Metyrapone | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 3 | Probing of the active site of microsomal cytochrome P-450 was carried out with a spin label derived from 2-methyl-1,2-bis(3-pyridyl)-1-propanone (metyrapone). | Metyrapone | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 4 | Its optical binding spectra to cytochrome P-450 resemble the spectra with metyrapone. | Metyrapone | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 5 | Since the apparent optical and EPR binding constants agree very well (Ks approximately 2-10(-5) M), and metyrapone is found to displace the spin label, we conclude, that the spin label binds to the active site of cytochrome P-450. | Metyrapone | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 6 | This supports the model that one of the pyridine nitrogens of metyrapone is coordinated to the iron of cytochrome P-450. | Metyrapone | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |