Title : The Y606C RET mutation causes a receptor gain of function.

Pub. Date : 2008 Aug

PMID : 18248647






1 Functional Relationships(s)
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1 RESULTS: We found that the cysteine insertion, due to the Y606C mutation, results in increased receptor dimerization, which is accompanied by an increased tyrosine phosphorylation of the Y905 residue in the RET/Y606C, demonstrating that the Y606C mutation is associated with constitutive receptor activation. Cysteine ret proto-oncogene Homo sapiens