Pub. Date : 2008 May 22
PMID : 18242899
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of this work was to investigate the effects of pluronic F68 block copolymer on the P-gp-mediated transport of celiprolol (CEL) and CYP3A4-mediated formation of midazolam (MDZ) metabolite 1"-hydroxymidazolam. | 1-hydroxymethylmidazolam | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | Furthermore, CYP3A4-catalyzed formation of 1"-hydroxymidazolam was inhibited by pluronic F68 with IC(50) and K(i) values of 0.11 and 0.16 mg/ml, respectively. | 1-hydroxymethylmidazolam | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |