Pub. Date : 2008 Mar 17
PMID : 18242595
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Geldanamycin enhances hepatocyte growth factor stimulation of eNOS phosphorylation in endothelial cells. | geldanamycin | nitric oxide synthase 3 | Homo sapiens |
| 2 | Treatment of endothelial cells with geldanamycin, a commonly used HSP90 inhibitor, augmented HGF-stimulated eNOS phosphorylation at Ser-1179, while it did not alter eNOS phosphorylation at Thr-497. | geldanamycin | nitric oxide synthase 3 | Homo sapiens |
| 3 | These results suggest that geldanamycin, but neither 17-AAG nor radicicol, may enhance HGF-mediated eNOS Ser-1179 phosphorylation by some as yet unknown mechanisms independently of HSP90 inhibition. | geldanamycin | nitric oxide synthase 3 | Homo sapiens |