Title : Involvement of DPP-IV catalytic residues in enzyme-saxagliptin complex formation.

Pub. Date : 2008 Feb

PMID : 18227430






1 Functional Relationships(s)
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1 To investigate whether this serine addition is assisted by the catalytic His-Asp dyad, we generated two mutants of DPP-IV, S630A and H740Q, and assayed them for ability to bind inhibitor. Serine dipeptidyl peptidase 4 Homo sapiens