Title : Effects of extracellular pH, PCO2 and HCO3- on intracellular pH in isolated type-I cells of the neonatal rat carotid body.

Pub. Date : 1991 Dec

PMID : 1822566






7 Functional Relationships(s)
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1 Simulated respiratory acidosis and alkalosis (i.e. changes in PCO2 at constant HCO3-) led to rapid (half-time t0.5 = 3 s) monotonic changes in pHi. pco2 glucose-6-phosphate isomerase Rattus norvegicus
2 Changes in PCO2 at constant pHo (i.e. simultaneously changing HCO3-) caused rapid transient changes in pHi but did not significantly affect steady-state pHi over the range 1-10% CO2. pco2 glucose-6-phosphate isomerase Rattus norvegicus
3 When PCO2 was held constant (5%), changing HCO3- and thus pHo (i.e. a simulated metabolic acidosis/alkalosis) led to much slower changes in pHi (t0.5 approximately 1 min). pco2 glucose-6-phosphate isomerase Rattus norvegicus
4 Therefore, over the range of pHo, PCO2 and [HCO3-]o tested, steady-state pHi appeared to be a unique function of pHo and independent of PCO2 and [HCO3-]o. pco2 glucose-6-phosphate isomerase Rattus norvegicus
5 Therefore, over the range of pHo, PCO2 and [HCO3-]o tested, steady-state pHi appeared to be a unique function of pHo and independent of PCO2 and [HCO3-]o. pco2 glucose-6-phosphate isomerase Rattus norvegicus
6 The close correlation between the effects of changing pHo, PCO2 and [HCO3-]o on pHi and on CSN discharge suggests that a change in type-I cell pHi is the first step in the chemoreception of blood pH by the carotid body. pco2 glucose-6-phosphate isomerase Rattus norvegicus
7 The close correlation between the effects of changing pHo, PCO2 and [HCO3-]o on pHi and on CSN discharge suggests that a change in type-I cell pHi is the first step in the chemoreception of blood pH by the carotid body. pco2 glucose-6-phosphate isomerase Rattus norvegicus