Title : Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage.

Pub. Date : 2008 Mar

PMID : 18208837






1 Functional Relationships(s)
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1 Time-dependent decrease was observed in APE1 mRNA and protein levels in the human colorectal cancer line HCT116 p53(+/+), but not in the isogenic p53 null mutant after treatment with camptothecin, a DNA topoisomerase I inhibitor. Camptothecin tumor protein p53 Homo sapiens