Title : Phenotypic and functional differentiation of KG-1 into dendritic-like cells.

Pub. Date : 2008

PMID : 18207029






1 Functional Relationships(s)
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1 Culture in the presence of TNF-alpha induced some differentiation, but only treatment with PMA and ionomycin (with or without prior culture in GM-CSF and IL-4) induced morphological and phenotypic changes consistent with DC-like maturation, and even these maximally differentiated KG-1 cells showed lower levels of surface marker expression, macromolecular endocytosis, and ability to stimulate in allogeneic MLR compared with in vitro monocyte-derived DCs. Ionomycin interleukin 4 Homo sapiens