Title : The contribution of c-Jun N-terminal kinase activation and subsequent Bcl-2 phosphorylation to apoptosis induction in human B-cells is dependent on the mode of action of specific stresses.

Pub. Date : 2008 Apr 1

PMID : 18201741






2 Functional Relationships(s)
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1 The goal of the present study was to determine the role of JNK pathway signaling for regulating B-cell apoptosis in two important but contrasting situations--global proteotoxic damage, induced by arsenite and hyperthermia, versus specific microtubule inhibition, induced by the anti-cancer drug vincristine, using the EW36 B-cell line. arsenite mitogen-activated protein kinase 8 Homo sapiens
2 Exposure of EW36 B-cells to arsenite or lethal hyperthermia resulted in activation of the JNK pathway and induction of apoptosis. arsenite mitogen-activated protein kinase 8 Homo sapiens