Title : Discovery and preliminary pharmacology of Sch 37370, a dual antagonist of PAF and histamine.

Pub. Date : 1991 Dec

PMID : 1819703






1 Functional Relationships(s)
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1 Sch 37370 selectively inhibits PAF-induced aggregation of human platelets in vitro (IC50 = 0.6 microM), and in vivo inhibits PAF- and histamine-induced bronchospasm in guinea pigs with ED50 values of 6.0 and 2.4 mg/kg p.o., respectively. Histamine PCNA clamp associated factor Homo sapiens