Pub. Date : 2008 May
PMID : 18194435
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of ATF-3 expression by B-Raf mediates the neuroprotective action of GW5074. | 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone | B-Raf proto-oncogene, serine/threonine kinase | Homo sapiens |
| 2 | Using low potassium (LK) induced apoptosis of cerebellar granule neurons, we report here that the protective action of GW5074 is mediated through the activation of B-Raf. | 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone | B-Raf proto-oncogene, serine/threonine kinase | Homo sapiens |
| 3 | Over-expression of a kinase-dead form of B-Raf blocks the ability of GW5074 to neuroprotect, whereas over-expression of active forms of B-Raf protect even in the absence of GW5074. | 5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone | B-Raf proto-oncogene, serine/threonine kinase | Homo sapiens |