Title : An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11.

Pub. Date : 2008 Mar

PMID : 18188187






1 Functional Relationships(s)
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1 Therefore, we have developed a mutant human CE (hCE1m6), based on the human liver CE hCE1, that can activate CPT-11 approximately 70-fold more efficiently than the wild-type protein and can be expressed at high levels in mammalian cells. Irinotecan carboxylesterase 1 Homo sapiens