Pub. Date : 2008 Apr
PMID : 18184925
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of central lactate metabolism lowers glucose production in uncontrolled diabetes and diet-induced insulin resistance. | Lactic Acid | insulin | Homo sapiens |
| 2 | RESEARCH DESIGN AND METHODS: We performed intracerebroventricular (ICV) administration of lactate to enhance central lactate metabolism in 1) early-onset streptozotocin-induced uncontrolled diabetic rodents, 2) experimentally induced hypoinsulinemic normal rodents, and 3) early-onset diet-induced insulin-resistant rodents. | Lactic Acid | insulin | Homo sapiens |
| 3 | Third, and finally, ICV lactate administration lowered glucose production in normal rodents with diet-induced insulin resistance. | Lactic Acid | insulin | Homo sapiens |
| 4 | CONCLUSIONS: Central lactate metabolism lowered glucose production in uncontrolled diabetic and normal rodents with hypoinsulinemia and in rodents with diet-induced insulin resistance. | Lactic Acid | insulin | Homo sapiens |