Title : Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus.

Pub. Date : 2008 Jan 9

PMID : 18184780






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Dephosphorylation of S408/9 unmasks a basic patch-binding motif for the clathrin adaptor AP2, enhancing the endocytosis of selected GABA(A)R subtypes from the plasma membrane during SE. gamma-Aminobutyric Acid transcription factor AP-2 alpha Homo sapiens
2 In agreement with this, enhancing S408/9 phosphorylation or selectively blocking the binding of the beta3 subunit to AP2 increased GABA(A)R cell surface expression levels and restored the efficacy of synaptic inhibition in SE. gamma-Aminobutyric Acid transcription factor AP-2 alpha Homo sapiens