Title : Akt activation is involved in P2Y12 receptor-mediated chemotaxis of microglia.

Pub. Date : 2008 May 15

PMID : 18183622






1 Functional Relationships(s)
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1 The Akt phosphorylation was blocked by U73122 and BAPTA-AM as well as by a phosphatidylinositol 3-kinase (PI3K) inhibitor, wortmannin, and inhibition of the Akt activation resulted in failure of chemotaxis. 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester AKT serine/threonine kinase 1 Homo sapiens