Title : Repositioning of ETO gene in cells treated with VP-16, an inhibitor of DNA-topoisomerase II.

Pub. Date : 2008 May 15

PMID : 18183572






2 Functional Relationships(s)
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1 But we further show that treatment of cells with VP-16 (etoposide), an inhibitor of DNA topoisomerase II widely used in anticancer chemotherapy, causes the ETO gene repositioning which allows AML1 and ETO genes to be localized in the same nuclear layer. Etoposide RUNX1 partner transcriptional co-repressor 1 Homo sapiens
2 But we further show that treatment of cells with VP-16 (etoposide), an inhibitor of DNA topoisomerase II widely used in anticancer chemotherapy, causes the ETO gene repositioning which allows AML1 and ETO genes to be localized in the same nuclear layer. Etoposide RUNX1 partner transcriptional co-repressor 1 Homo sapiens