Title : OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells.

Pub. Date : 2008 Apr

PMID : 18182481






2 Functional Relationships(s)
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Protein Name
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1 In parallel, OSU caused PERK-dependent increases in 70-kDa heat shock protein (HSP70) expression and decreases in 90-kDa heat shock protein (HSP90) and Grp78/BiP expression. osu heat shock protein family A (Hsp70) member 4 Homo sapiens
2 Knock-down or small-molecule inhibition of HSP70 expression enhanced OSU toxicity, and overexpression of HSP70 suppressed OSU-induced low pH vesicle formation and lethality. osu heat shock protein family A (Hsp70) member 4 Homo sapiens