Title : CTL-mediated selective pressure influences dynamic evolution and pathogenic functions of HIV-1 Nef.

Pub. Date : 2008 Jan 15

PMID : 18178851






1 Functional Relationships(s)
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1 By genetic and functional studies, we found that Arg75Thr and Tyr85Phe mutations, located in a well-conserved proline-rich region in Nef, were differently associated with escape from CTL responses specific for two overlapping HLA-B35-restricted epitopes. Proline S100 calcium binding protein B Homo sapiens