Title : Transcriptional regulation of human UGT1A1 gene expression through distal and proximal promoter motifs: implication of defects in the UGT1A1 gene promoter.

Pub. Date : 2008 Jun

PMID : 18172616






1 Functional Relationships(s)
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1 Human UDP-glucuronosyltransferase (UGT)1A1 is a critical enzyme responsible for detoxification and metabolism of endogenous and exogenous lipophilic compounds, such as potentially neurotoxic bilirubin and the anticancer drug irinotecan SN-38, via conjugation with glucuronic acid. Glucuronic Acid UDP glucuronosyltransferase family 1 member A1 Homo sapiens