Pub. Date : 2007 Dec
PMID : 18171992
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In cultured primary keratinocytes, TPA treatment also led to activation of Akt. | Tetradecanoylphorbol Acetate | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | Activation of the epidermal growth factor receptor (EGFR) seemed to underlie the ability of TPA to activate Akt as both PD153035, an inhibitor of EGFR, and GW2974, a dual-specific inhibitor of both EGFR and erbB2, were able to effectively reduce TPA-induced Akt phosphorylation as well as TPA-stimulated EGFR and erbB2 tyrosine phosphorylation in a dose-dependent manner. | Tetradecanoylphorbol Acetate | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | Activation of the epidermal growth factor receptor (EGFR) seemed to underlie the ability of TPA to activate Akt as both PD153035, an inhibitor of EGFR, and GW2974, a dual-specific inhibitor of both EGFR and erbB2, were able to effectively reduce TPA-induced Akt phosphorylation as well as TPA-stimulated EGFR and erbB2 tyrosine phosphorylation in a dose-dependent manner. | Tetradecanoylphorbol Acetate | thymoma viral proto-oncogene 1 | Mus musculus |
| 4 | However, combination of EGFR inhibitor and PKC inhibitor completely abrogated TPA-induced activation of Akt. | Tetradecanoylphorbol Acetate | thymoma viral proto-oncogene 1 | Mus musculus |