Title : Development of an in vitro reproductive screening assay for novel pharmaceutical compounds.

Pub. Date : 2008 Oct

PMID : 18171324






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 MLTC-1 cells only produce the reproductive hormone progesterone in response to hCG (human chorionic gonadotropin), which stimulated progesterone production dose-dependently from 0 to 100 m.i.u. Progesterone chorionic gonadotropin subunit beta 5 Homo sapiens
2 hCG-stimulated progesterone synthesis afforded some protection against the cytotoxic effects of the two novel nanotechnology compounds; therefore doses < or =100 microg/ml and an exposure period of 1 h would be recommended for testing in in vivo animal reproductive assays. Progesterone chorionic gonadotropin subunit beta 5 Homo sapiens