Pub. Date : 2008 Mar
PMID : 18164739
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lathosterol side chain amides: a new class of human lathosterol oxidase inhibitors. | Amides | sterol-C5-desaturase | Homo sapiens |
| 2 | In this paper we report on lathosterol side chain amides as a new class of selective lathosterol oxidase inhibitors. | Amides | sterol-C5-desaturase | Homo sapiens |
| 3 | Small alkyl residues at the amide nitrogen (hydrogen and methyl) lead to an inhibition of the enzyme Delta24-reductase, the N-ethyl and N-propyl derivatives show a dual action, inhibiting both Delta24-reductase and lathosterol oxidase. | Amides | sterol-C5-desaturase | Homo sapiens |
| 4 | Lathosterol-derived amides with larger substituents (butyl, isobutyl, tert-butyl, pentyl) at the amide nitrogen were found to be selective inhibitors of lathosterol oxidase. | Amides | sterol-C5-desaturase | Homo sapiens |