Pub. Date : 1991
PMID : 1811246
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Northern blot analysis of Type II GR mRNA showed that treatment of male rats with either desipramine or imipramine increased hypothalamic and hippocampal GR mRNA levels. | Imipramine | nuclear receptor subfamily 3, group C, member 1 | Rattus norvegicus |
| 2 | Northern blot analysis of Type II GR mRNA showed that treatment of male rats with either desipramine or imipramine increased hypothalamic and hippocampal GR mRNA levels. | Imipramine | nuclear receptor subfamily 3, group C, member 1 | Rattus norvegicus |
| 3 | Upregulation of GR mRNA following administration of imipramine was found in brain regions of female rats, while desipramine had no effect. | Imipramine | nuclear receptor subfamily 3, group C, member 1 | Rattus norvegicus |
| 4 | We conclude that desipramine, imipramine, ketanserin and lithium can modulate GR mRNA in regions of rat brain involved in the control of the HPA axis and may have a common mechanism of action at the level of the GR gene. | Imipramine | nuclear receptor subfamily 3, group C, member 1 | Rattus norvegicus |
| 5 | We conclude that desipramine, imipramine, ketanserin and lithium can modulate GR mRNA in regions of rat brain involved in the control of the HPA axis and may have a common mechanism of action at the level of the GR gene. | Imipramine | nuclear receptor subfamily 3, group C, member 1 | Rattus norvegicus |