Title : Effects of aspirin, nimesulide, and SC-560 on vasopressin-induced contraction of human gastroepiploic artery and saphenous vein.

Pub. Date : 2008 Jan

PMID : 18090373






2 Functional Relationships(s)
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1 The COX-1 and COX-2 inhibitor aspirin (10(-6)-10(-5) mol/L) and the COX-2 inhibitor nimesulide (10(-6) mol/L) induced leftward shifts of the concentration-response curve for vasopressin in gastroepiploic artery. nimesulide mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 CONCLUSION: The results provide functional evidence that aspirin at high concentrations and the COX-2 selective inhibitor nimesulide potentiate the contractile response of gastroepiploic artery to vasopressin, thus suggesting the release of relaxant prostaglandins by the peptide. nimesulide mitochondrially encoded cytochrome c oxidase II Homo sapiens