Title : A displaced PAG enhances proximal signaling and SDF-1-induced T cell migration.

Pub. Date : 2008 Jan

PMID : 18085663






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 PAG, the phosphoprotein associated with glycosphingolipid-enriched microdomains (GEM), negatively regulates Src family kinases by recruiting C-terminal Src kinase (Csk) to the membrane, where Csk phosphorylates the inhibitory tyrosine of the Src kinases. phenylacetylglycine C-terminal Src kinase Homo sapiens
2 PAG, the phosphoprotein associated with glycosphingolipid-enriched microdomains (GEM), negatively regulates Src family kinases by recruiting C-terminal Src kinase (Csk) to the membrane, where Csk phosphorylates the inhibitory tyrosine of the Src kinases. phenylacetylglycine C-terminal Src kinase Homo sapiens
3 PAG, the phosphoprotein associated with glycosphingolipid-enriched microdomains (GEM), negatively regulates Src family kinases by recruiting C-terminal Src kinase (Csk) to the membrane, where Csk phosphorylates the inhibitory tyrosine of the Src kinases. phenylacetylglycine C-terminal Src kinase Homo sapiens
4 Despite being displaced, the mutant PAG molecule still binds the Src kinase Fyn and the cytoskeletal adaptor ezrin-radixin-moesin-binding phosphoprotein of 50 kDa, becomes tyrosine-phosphorylated, and recruits Csk to the membrane. phenylacetylglycine C-terminal Src kinase Homo sapiens