Title : A PARP-1/JNK1 cascade participates in the synergistic apoptotic effect of TNFalpha and all-trans retinoic acid in APL cells.

Pub. Date : 2008 May 29

PMID : 18084321






3 Functional Relationships(s)
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1 We report that nanomolar concentrations of all-trans retinoic acid (ATRA) amplify TNFalpha-induced apoptosis in APL cells expressing a specific repressor of NF-kappaB activation. Tretinoin tumor necrosis factor Homo sapiens
2 We report that nanomolar concentrations of all-trans retinoic acid (ATRA) amplify TNFalpha-induced apoptosis in APL cells expressing a specific repressor of NF-kappaB activation. Tretinoin tumor necrosis factor Homo sapiens
3 This study also suggests that inclusion of nanomolar doses of ATRA could be clinically beneficial in amplifying TNFalpha-induced antitumor signals. Tretinoin tumor necrosis factor Homo sapiens