Pub. Date : 2008 Jun
PMID : 18082883
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Retinoid X receptor alpha is highly phosphorylated in retinoic acid-resistant HL-60R cells and the combination of 9-cis retinoic acid plus MEK inhibitor induces apoptosis in the cells. | Tretinoin | retinoid X receptor alpha | Homo sapiens |
| 2 | We examined the effects of 9-cis retinoic acid (RA) on the expression levels of retinoid X receptor alpha (RXR alpha) and its phosphorylated form (p-RXR alpha) in HL-60 and HL-60R cells. | Tretinoin | retinoid X receptor alpha | Homo sapiens |
| 3 | We examined the effects of 9-cis retinoic acid (RA) on the expression levels of retinoid X receptor alpha (RXR alpha) and its phosphorylated form (p-RXR alpha) in HL-60 and HL-60R cells. | Tretinoin | retinoid X receptor alpha | Homo sapiens |
| 4 | We examined the effects of 9-cis retinoic acid (RA) on the expression levels of retinoid X receptor alpha (RXR alpha) and its phosphorylated form (p-RXR alpha) in HL-60 and HL-60R cells. | Tretinoin | retinoid X receptor alpha | Homo sapiens |
| 5 | 9-cis RA reduced both RXR alpha and p-RXR alpha in HL-60 cells, but did neither in HL-60R cells. | Tretinoin | retinoid X receptor alpha | Homo sapiens |
| 6 | 9-cis RA reduced both RXR alpha and p-RXR alpha in HL-60 cells, but did neither in HL-60R cells. | Tretinoin | retinoid X receptor alpha | Homo sapiens |
| 7 | However, when the HL-60R cells were treated with the combination of 9-cis RA plus PD98059, MEK inhibitor, the p-RXR alpha and RXR alpha proteins all markedly decreased. | Tretinoin | retinoid X receptor alpha | Homo sapiens |
| 8 | However, when the HL-60R cells were treated with the combination of 9-cis RA plus PD98059, MEK inhibitor, the p-RXR alpha and RXR alpha proteins all markedly decreased. | Tretinoin | retinoid X receptor alpha | Homo sapiens |
| 9 | Phosphorylation of RXR alpha might be associated with RA-resistance in HL-60R cells. | Tretinoin | retinoid X receptor alpha | Homo sapiens |