Title : Retinoid X receptor alpha is highly phosphorylated in retinoic acid-resistant HL-60R cells and the combination of 9-cis retinoic acid plus MEK inhibitor induces apoptosis in the cells.

Pub. Date : 2008 Jun

PMID : 18082883






2 Functional Relationships(s)
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Protein Name
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1 Retinoid X receptor alpha is highly phosphorylated in retinoic acid-resistant HL-60R cells and the combination of 9-cis retinoic acid plus MEK inhibitor induces apoptosis in the cells. Tretinoin mitogen-activated protein kinase kinase 7 Homo sapiens
2 However, when the HL-60R cells were treated with the combination of 9-cis RA plus PD98059, MEK inhibitor, the p-RXR alpha and RXR alpha proteins all markedly decreased. Tretinoin mitogen-activated protein kinase kinase 7 Homo sapiens