Title : Folic acid administration produces an antidepressant-like effect in mice: evidence for the involvement of the serotonergic and noradrenergic systems.

Pub. Date : 2008 Feb

PMID : 18078962






2 Functional Relationships(s)
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1 Moreover, the pretreatment of mice with WAY100635 (0.1mg/kg, s.c., a selective 5-HT(1A) receptor antagonist) blocked the decrease in immobility time in the FST elicited by folic acid (50mg/kg, p.o. Folic Acid 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus
2 Overall, the results firstly indicate that folic acid produced an antidepressant-like effect in FST and in TST and that this effect appears to be mediated by an interaction with the serotonergic (5-HT(1A) and 5-HT(2A/2C) receptors) and noradrenergic (alpha(1)- and alpha(2)-adrenoceptors) systems. Folic Acid 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus