Pub. Date : 2008 May
PMID : 18078766
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phosphoinositide-3-kinase (PI3K)/Akt, survivin, bcl-2 were significantly downregulated in cells treated with the combination of celecoxib and cisplatin, and decreased survivin and bcl-2 levels were found in cells with wortmannin, a specific PI3K inhibitor. | Celecoxib | BCL2 apoptosis regulator | Homo sapiens |
| 2 | Phosphoinositide-3-kinase (PI3K)/Akt, survivin, bcl-2 were significantly downregulated in cells treated with the combination of celecoxib and cisplatin, and decreased survivin and bcl-2 levels were found in cells with wortmannin, a specific PI3K inhibitor. | Celecoxib | BCL2 apoptosis regulator | Homo sapiens |
| 3 | Therefore, celecoxib exerts its anti-tumor activities through COX-2-independent mechanisms, which may be PI3K/Akt-dependent, and survivin and bcl-2-related. | Celecoxib | BCL2 apoptosis regulator | Homo sapiens |
| 4 | PI3K may be at the center of the celecoxib effects, which play an essential role in the regulation of survivin and Bcl-2. | Celecoxib | BCL2 apoptosis regulator | Homo sapiens |