Pub. Date : 2008 Jan
PMID : 18078440
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Farnesol and dodecanol effects on the Candida albicans Ras1-cAMP signalling pathway and the regulation of morphogenesis. | Farnesol | Ras family GTPase RAS1 | Saccharomyces cerevisiae S288C |
| 2 | Candida albicans hypha formation which has been stimulated via the Ras1-cAMP-Efg1 signalling cascade is inhibited by farnesol, a C. albicans autoregulatory factor, and small molecules such as dodecanol. | Farnesol | Ras family GTPase RAS1 | Saccharomyces cerevisiae S288C |
| 3 | Two transcripts, CTA1 and HSP12, which are at higher levels upon mutation of Ras1 or Cdc35, were increased in abundance in cells grown with farnesol or dodecanol. | Farnesol | Ras family GTPase RAS1 | Saccharomyces cerevisiae S288C |
| 4 | Because several cAMP-controlled outputs are affected by farnesol and dodecanol, our findings suggest that these compounds impact activity of the Ras1-Cdc35 pathway, thus leading to an alteration of C. albicans morphology. | Farnesol | Ras family GTPase RAS1 | Saccharomyces cerevisiae S288C |