Title : Solamargine enhances HER2 expression and increases the susceptibility of human lung cancer H661 and H69 cells to trastuzumab and epirubicin.

Pub. Date : 2008 Feb

PMID : 18078328






2 Functional Relationships(s)
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1 After treatment with SM, coexpression of HER2 and topoisomerase IIalpha (TOP2A) H661 and H69 cells is more sensitive to the TOP2 inhibitor, epirubicin. Epirubicin erb-b2 receptor tyrosine kinase 2 Homo sapiens
2 The data presented herein suggest that the expression of HER2 did not influence the SM-induced apoptosis of different types of lung cancer cells and that the SM up-regulation of HER2 and TOP2A expressions simultaneously augmented trastuzumab and epirubicin-induced deaths of lung cancer H661 and H69 cells. Epirubicin erb-b2 receptor tyrosine kinase 2 Homo sapiens