Title : Inhibition of matrix metalloproteinase-9 gene expression by an isoflavone metabolite, irisolidone in U87MG human astroglioma cells.

Pub. Date : 2008 Feb 8

PMID : 18070596






1 Functional Relationships(s)
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1 Further mechanistic studies revealed that irisolidone inhibits the binding of NF-kappaB and AP-1 to the MMP-9 promoter and suppresses the PMA-induced phosphorylation of ERK and JNK, which are upstream signaling molecules in MMP-9 expression. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 8 Homo sapiens