Title : Design, synthesis, and biological evaluation of human sialidase inhibitors. Part 1: selective inhibitors of lysosomal sialidase (NEU1).

Pub. Date : 2008 Jan 15

PMID : 18068975






1 Functional Relationships(s)
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1 A series of amide-linked C9 modified DANA (2-deoxy-2,3-dehydro-N-acetylneuraminic acid) analogues were synthesized and their inhibitory activities against all four human sialidases (NEU1-NEU4) were determined. 2-deoxy-2,3-dehydro-N-acetylneuraminic acid neuraminidase 4 Homo sapiens